RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

被引：258

作者：

Bucciarelli, LG ^{[1
]}

Wendt, T ^{[1
]}

Rong, L ^{[1
]}

Lalla, E ^{[1
]}

Hofmann, MA ^{[1
]}

Goova, MT ^{[1
]}

Taguchi, A ^{[1
]}

Yan, SF ^{[1
]}

Yan, SD ^{[1
]}

Stern, DM ^{[1
]}

Schmidt, AM ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 07期

关键词：

receptor; diabetes; vasculopathy; atherosclerosis; immunoglobulin; superfamily; inflammation; cancer;

D O I：

10.1007/s00018-002-8491-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

引用

页码：1117 / 1128

页数：12

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