RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

被引：258

作者：

Bucciarelli, LG ^{[1
]}

Wendt, T ^{[1
]}

Rong, L ^{[1
]}

Lalla, E ^{[1
]}

Hofmann, MA ^{[1
]}

Goova, MT ^{[1
]}

Taguchi, A ^{[1
]}

Yan, SF ^{[1
]}

Yan, SD ^{[1
]}

Stern, DM ^{[1
]}

Schmidt, AM ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 07期

关键词：

receptor; diabetes; vasculopathy; atherosclerosis; immunoglobulin; superfamily; inflammation; cancer;

D O I：

10.1007/s00018-002-8491-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

引用

页码：1117 / 1128

页数：12

共 83 条

[31] Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice [J].

Kislinger, T ;

Tanji, N ;

Wendt, T ;

Qu, W ;

Lu, Y ;

Ferran, LJ ;

Taguchi, A ;

Olson, K ;

Bucciarelli, L ;

Goova, M ;

Hofmann, MA ;

Cataldegirmen, G ;

D'Agati, V ;

Pischetsrieder, M ;

Stern, DM ;

Schmidt, AM .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (06) :905-910

[32]

Kuehn Ralf, 1993, Cell, V75, P263

[33] Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice [J].

Lalla, E ;

Lamster, IB ;

Feit, M ;

Huang, L ;

Spessot, A ;

Qu, W ;

Kislinger, T ;

Lu, Y ;

Stern, DM ;

Schmidt, AM .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (08) :1117-1124

[34]

Lalla E, 1998, J PERIODONTAL RES, V33, P387

[35] Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress [J].

Lander, HM ;

Tauras, JM ;

Ogiste, JS ;

Hori, O ;

Moss, RA ;

Schmidt, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (28) :17810-17814

[36]

Lee EJ, 1997, J FORMOS MED ASSOC, V96, P5

[37] Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products [J].

Li, JF ;

Schmidt, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) :16498-16506

[38] Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells [J].

Li, JF ;

Qu, XQ ;

Schmidt, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (47) :30870-30878

[39] Molecular identity and cellular distribution of advanced glycation endproduct receptors: Relationship of p60 to OST-48 and p90 to 80K-H membrane proteins [J].

Li, YM ;

Mitsuhashi, T ;

Wojciechowicz, D ;

Shimizu, N ;

Li, J ;

Stitt, A ;

He, CJ ;

Banerjee, D ;

Vlassara, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :11047-11052

[40] PERIODONTAL-DISEASE - THE 6TH COMPLICATION OF DIABETES-MELLITUS [J].

LOE, H .

DIABETES CARE, 1993, 16 (01) :329-334

← 1 2 3 4 5 6 7 8 9 →