Distributions of transmitter receptors in the macaque cingulate cortex

被引:44
作者
Bozkurt, A
Zilles, K
Schleicher, A
Kamper, L
Arigita, ES
Uylings, HBM
Kötter, R
机构
[1] Univ Dusseldorf, C & O Vogt Inst Himforsch, D-40225 Dusseldorf, Germany
[2] Forschungszentrum Julich, Res Ctr, Inst Med, D-52425 Julich, Germany
[3] Netherlands Inst Brain Res, NL-1105 AZ Amsterdam ZO, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Anat, Amsterdam, Netherlands
[5] Univ Dusseldorf, Inst Anat 2, D-40225 Dusseldorf, Germany
关键词
cerebral cortex; cytoarchitecture; mapping; multivariate statistics; neurotransmitter; primate;
D O I
10.1016/j.neuroimage.2004.10.040
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The primate cingulate cortex is structurally and functionally complex. Although no studies have investigated the regional densities of multiple neurotransmitter receptor systems, such information would be useful for assessing its functions and disease vulnerabilities. We quantified nine different receptors in five transmitter systems by in vitro autoradiographic mapping of the cingulate cortex of macaque monkeys with the aim to link cytoarchitectonic regions and functional specialization. Receptor mapping substantiated the subdivision of the cingulate cortex into anterior versus posterior regions. In anterior cingulate cortex (ACC)AMPA glutamatergic receptors and GABA(A) inhibitory receptors were present in significantly higher concentrations than the modulatory alpha-adrenergic and muscarinic receptors. These differences were absent in the posterior cingulate cortex (PCC). By contrast, NMDA receptor densities were significantly higher than AMPA receptor densities in PCC, but not in ACC. The midcingulate area 24' shared more features with ACC than PCC. This area was characterized by the highest ratios of NMDA receptors to alpha-adrenergic, muscarinic and 5-HT2 receptors among all cingulate regions. Compared to rostrocaudal divisions, the differences between dorsoventral subdivisions a-c were small in all regions of cingulate cortex, and only muscarinic and alpha-adrenergic receptor densities followed the degree of cytoarchitectonic differentiation. We conclude that multiple receptor mapping reveals a highly differentiated classification of cingulate cortex with a characteristic predominance of fast ionotropic excitatory and inhibitory receptors in ACC, but a strong and varied complement of NMDA and metabotropic receptors in PCC. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:219 / 229
页数:11
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