Luteal phase progesterone increases live birth rate after frozen embryo transfer

被引：93

作者：

Bjuresten, Kerstin ^{[1
]}

Landgren, Britt-Marie ^{[1
]}

Hovatta, Outi ^{[1
]}

Stavreus-Evers, Anneli ^{[2
]}

机构：

[1] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

[2] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 02期

关键词：

Progesterone; pregnancy rate; live birth rate; frozen embryo transfer; natural menstrual cycle; IN-VITRO FERTILIZATION; MICRONIZED PROGESTERONE; VAGINAL PROGESTERONE; HUMAN ENDOMETRIUM; TRANSFER CYCLES; SUPPORT; SUPPLEMENTATION;

D O I：

10.1016/j.fertnstert.2010.05.019

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles. Design: Prospective randomized controlled trial. Setting: University-based hospital. Subject(s): Four hundred thirty-five women undergoing embryo transfer in natural cycles. Intervention(s): The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support. Main Outcome Measure(s): Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate. Result(s): Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate. Conclusion(s): Progesterone supplementation improves live birth rate after embryo transfer in natural cycles. (Fertil Steril (R) 2011;95:534-7. (C)2011 by American Society for Reproductive Medicine.)

引用

页码：534 / 537

页数：4

共 19 条

[1]

BUVAT J, 1990, FERTIL STERIL, V53, P490

[2] Pharmacokinetics and endometrial effects of the vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women [J].

Cicinelli, E ;

Mazzotta, N ;

Borraccino, V ;

Cerundolo, ML ;

Petruzzi, D ;

Schonauer, LM .

FERTILITY AND STERILITY, 1996, 65 (04) :860-862

[3] Hormone Receptor Dynamics in a Receptive Human Endometrium [J].

Critchley, Hilary O. D. ;

Saunders, Philippa T. K. .

REPRODUCTIVE SCIENCES, 2009, 16 (02) :191-199

[4] SIGNIFICANCE OF HUMAN CORPUS-LUTEUM IN PREGNANCY MAINTENANCE .1. PRELIMINARY STUDIES [J].

CSAPO, AI ;

WIEST, WG ;

SAUVAGE, JP ;

RUTTNER, B ;

PULKKINEN, MO .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1972, 112 (08) :1061-+

[5] Transvaginal administration of progesterone [J].

Fanchin, R ;

DeZiegler, D ;

Bergeron, C ;

Righini, C ;

Torrisi, C ;

Frydman, R .

OBSTETRICS AND GYNECOLOGY, 1997, 90 (03) :396-401

[6] Cryopreserved-thawed embryo transfer in natural or down-regulated hormonally controlled cycles: a retrospective study [J].

Gelbaya, TA ;

Nardo, LG ;

Hunter, HR ;

Fitzgerald, CT ;

Horne, G ;

Pease, EEH ;

Brison, DR ;

Lieberman, BA .

FERTILITY AND STERILITY, 2006, 85 (03) :603-609

[7] Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients [J].

Haouzi, D. ;

Assou, S. ;

Mahmoud, K. ;

Tondeur, S. ;

Reme, T. ;

Hedon, B. ;

De Vos, J. ;

Hamamah, S. .

HUMAN REPRODUCTION, 2009, 24 (06) :1436-1445

[8] Matched-samples comparison of intramuscular versus vaginal progesterone for luteal phase support after in vitro fertilization and embryo transfer [J].

Khan, Naveed ;

Richter, Kevin S. ;

Newsome, Tasha L. ;

Blake, Emily J. ;

Yankov, Vladimir L. .

FERTILITY AND STERILITY, 2009, 91 (06) :2445-2450

[9]

KIMZEY LM, 1991, FERTIL STERIL, V56, P995

[10] Disrupted gene pattern in patients with repeated in vitro fertilization (IVF) failure [J].

Koler, Moriah ;

Achache, Hanna ;

Tsafrir, Avi ;

Smith, Yoav ;

Revel, Ariel ;

Reich, Reuven .

HUMAN REPRODUCTION, 2009, 24 (10) :2541-2548

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