Clinical strategies to enhance T cell reconstitution

被引：51

作者：

Goldberg, Gabrielle L. ^{[1
]}

Zakrzewski, Johannes L. ^{[1
]}

Perales, Miguel A. ^{[1
]}

van den Brink, Marcel R. M. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Immunol Bone Transplantat, Dept Immunol, New York, NY 10021 USA

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 05期

关键词：

T cell reconstitution; bone marrow transplantation; interleukin-7; keratinocyte growth factor; growth hormone; sex steroid modulation; OP9-DL1;

D O I：

10.1016/j.smim.2007.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：289 / 296

页数：8

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