IL-7 and IL-15:: therapeutic cytokines for immunodeficiency

被引：119

作者：

Alpdogan, Ö ^{[1
]}

van den Brink, MRM ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.it.2004.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.

引用

页码：56 / 64

页数：9

共 94 条

[1] Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice
AbdulHai, A
BenYehuda, A
Weiss, L
Friedman, G
ZakayRones, Z
Slavin, S
Or, R
[J]. BONE MARROW TRANSPLANTATION, 1997, 19 (06) : 539 - 543
[2] Thymopoiesis independent of common lymphoid progenitors
Allman, D
Sambandam, A
Kim, S
Miller, JP
Pagan, A
Well, D
Meraz, A
Bhandoola, A
[J]. NATURE IMMUNOLOGY, 2003, 4 (02) : 168 - 174
[3] Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
Alpdogan, O
Schmaltz, C
Muriglan, SJ
Kappel, BJ
Perales, MA
Rotolo, JA
Halm, JA
Rich, BE
van den Brink, MRM
[J]. BLOOD, 2001, 98 (07) : 2256 - 2265
[4] IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
Alpdogan, Ö
Muriglan, SJ
Eng, JM
Willis, LM
Greenberg, AS
Kappel, B
van den Brink, MRM
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (07) : 1095 - 1107
[5] ALPODOGAN O, 2004, BLOOD, DOI DOI 10.1182/BLOOD-2003-09-3344
[6] IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro
Alves, NL
Hooibrink, B
Arosa, FA
van Lier, RAW
[J]. BLOOD, 2003, 102 (07) : 2541 - 2546
[7] Levels of interleukin-15 in plasma may predict a favorable outcome of structured treatment interruption in patients with chronic human immunodeficiency virus infection
Amicosante, M
Poccia, F
Gioia, C
Montesano, C
Topino, S
Martini, F
Narciso, P
Pucillo, LP
D'Offizi, G
[J]. JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (05) : 661 - 665
[8] ARIIZUMI K, 1995, J IMMUNOL, V154, P6031
[9] Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation
Bamford, RN
Battiata, AP
Burton, JD
Sharma, H
Waldmann, TA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) : 2897 - 2902
[10] Beckett S, 2002, CALL CENT MAG, V15, P8

← 1 2 3 4 5 6 7 8 9 10 →