IL-7 and IL-15:: therapeutic cytokines for immunodeficiency

被引：119

作者：

Alpdogan, Ö ^{[1
]}

van den Brink, MRM ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.it.2004.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.

引用

页码：56 / 64

页数：9

共 94 条

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