National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006

被引:380
作者
Liu, Andrew H. [1 ,2 ]
Jaramillo, Renee [3 ]
Sicherer, Scott H. [4 ]
Wood, Robert A. [5 ]
Bock, S. Allan [1 ,2 ]
Burks, A. Wesley [6 ]
Massing, Mark [3 ]
Cohn, Richard D. [3 ]
Zeldin, Darryl C. [7 ]
机构
[1] Natl Jewish Hlth, Denver, CO 80206 USA
[2] Univ Colorado, Denver Sch Med, Denver, CO 80202 USA
[3] SRA Int Inc, Durham, NC USA
[4] Mt Sinai Sch Med, Jaffe Food Allergy Inst, New York, NY USA
[5] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[6] Duke Univ, Med Ctr, Durham, NC USA
[7] NIEHS, NIH, Res Triangle Pk, NC 27709 USA
关键词
Asthma; eczema; egg; food allergy; food sensitization; food-specific serum IgE; peanut; hay fever; milk; prevalence; risk; shrimp; IGE CONCENTRATIONS; CHILDREN; HYPERSENSITIVITY; POPULATION; CHALLENGES; REACTIVITY; PEANUT;
D O I
10.1016/j.jaci.2010.07.026
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: The national prevalence and patterns of food allergy (FA) in the United States are not well understood. Objective: We developed nationally representative estimates of the prevalence of and demographic risk factors for FA and investigated associations of FA with asthma, hay fever, and eczema. Methods: A total of 8203 participants in the National Health and Nutrition Examination Survey 2005-2006 had food-specific serum IgE measured to peanut, cow's milk, egg white, and shrimp. Food-specific IgE and age-based criteria were used to define likely FA (LFA), possible FA, and unlikely FA and to develop estimates of clinical FA. Self-reported data were used to evaluate demographic risk factors and associations with asthma and related conditions. Results: In the United States, the estimated prevalence of clinical FA was 2.5% (peanut, 1.3%; milk, 0.4%; egg, 0.2%; shrimp, 1.0%; not mutually exclusive). Risk of possible FA/LFA was increased in non-Hispanic blacks (odds ratio, 3.06; 95% CI, 2.14-4.36), males (1.87; 1.32-2.66), and children (2.04; 1.42-2.93). Study participants with doctor-diagnosed asthma (vs no asthma) exhibited increased risk of all measures of food sensitization. Moreover, in those with LFA, the adjusted odds ratio for current asthma (3.8; 1.5-10.7) and an emergency department visit for asthma in the past year (6.9; 2.4-19.7) were both notably increased. Conclusion: Population-based serologic data on 4 foods indicate an estimated 2.5% of the US population has FA, and increased risk was found for black subjects, male subjects, and children. In addition, FA could be an under-recognized risk factor for problematic asthma. (J Allergy Clin Immunol 2010;126:798-806.)
引用
收藏
页码:798 / U186
页数:22
相关论文
共 31 条
[1]  
[Anonymous], ANAL REPORTING GUIDE
[2]   Prevalences of positive skin test responses to 10 common allergens in the US population: Results from the Third National Health and Nutrition Examination Survey [J].
Arbes, SJ ;
Gergen, PJ ;
Elliott, L ;
Zeldin, DC .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (02) :377-383
[3]  
ARIANA C, 2010, J ALLERGY CLIN IMMUN, V125, P872
[4]   Food allergy as a risk factor for asthma morbidity in adults [J].
Berns, Stephen H. ;
Halm, Ethan A. ;
Sampson, Hugh A. ;
Sicherer, Scott H. ;
Busse, Paula J. ;
Wisnivesky, Juan P. .
JOURNAL OF ASTHMA, 2007, 44 (05) :377-381
[5]  
Bock S A., 1992, Pediatr Allergy Immunol, V3, P188, DOI DOI 10.1111/J.1399-3038.1992.TB00048.X
[6]   Fatalities due to anaphylactic reactions to foods [J].
Bock, SA ;
Muñoz-Furlong, A ;
Sampson, HA .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (01) :191-193
[7]  
BOCK SA, 1987, PEDIATRICS, V79, P683
[8]   Food Allergy Among Children in the United States [J].
Branum, Amy M. ;
Lukacs, Susan L. .
PEDIATRICS, 2009, 124 (06) :1549-1555
[9]  
Branum Amy M, 2008, NCHS Data Brief, P1
[10]   Exercise-induced anaphylaxis (EIA) [J].
Castells, MC ;
Horan, RF ;
Sheffer, AL .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 1999, 17 (04) :413-424