Catalytic aminohydroxylation using adenine-derivatives as the nitrogen source

被引：11

作者：

Dress, KR

Goossen, LJ

Liu, H

Jerina, DM ^{[1
]}

Sharpless, KB

机构：

[1] NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 42期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01716-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-chloro-N-sodio salts of adenine derivatives are suitable nitrogen sources for the osmium catalyzed aminohydroxylation of olefins, achieving suprafacial, vicinal addition of adenine and a hydroxyl group. The scope of this transformation was examined using adenine and adenosine-derivatives in conjunction with three different olefins. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：7669 / 7672

页数：4

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