SYNTHESIS OF DEOXYADENOSINE ADDUCTS FROM THE HIGHLY CARCINOGENIC FJORD REGION DIOL EPOXIDE OF BENZO[C]PHENANTHRENE

被引：13

作者：

LAKSHMAN, MK ^{[1
]}

YEH, HJC ^{[1
]}

YAGI, H ^{[1
]}

JERINA, DM ^{[1
]}

机构：

[1] NIDDK,BIOORGAN & ANALYT CHEM LAB,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期

关键词：

POLYCYCLIC HYDROCARBONS; BENZO[C]PHENANTHRENE 3,4-DIOL 1,2-EPOXIDE; DEOXYADENOSINE ADDUCTS;

D O I：

10.1016/S0040-4039(00)60852-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unlike bay-region diol epoxides, the fjord-region benzo[c]phenanthrene 3,4-diol 1,2-epoxide-2 (4-hydroxyl and epoxide oxygen trans) undergoes non-regioselective ring opening by both ammonia and azide anion. Adducts corresponding to a benzylic and non-benzylic S(N)2 ring opening by N6 of deoxyadenosine have been characterized.

引用

页码：7121 / 7124

页数：4

共 16 条

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