Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

被引:192
作者
Etminan, M
Gill, SS
Samii, A
机构
[1] Royal Victoria Hosp, Div Clin Epidemiol, Montreal, PQ H3A 1A2, Canada
[2] McGill Univ, Montreal, PQ H3A 2T5, Canada
[3] Queens Univ, Dept Med, Kingston, ON K7L 3N6, Canada
[4] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
D O I
10.1016/S1474-4422(05)70097-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied the effect of vitamin C, vitamin E, and P carotene intake on the risk of Parkinson's disease (PD). We did a systematic review and meta-analysis of observational studies published between 1966 and March 2005 searching MEDLINE, EMBASE, and the Cochrane Library. Eight studies were identified (six case-control, one cohort, and one cross-sectional). We found that dietary intake of vitamin E protects against PD. This protective influence was seen with both moderate intake (relative risk 0 (.) 81, 95% CI 0(.)67-0(.)98) and high intake (0(.)78, 0(.)57-1(.)06) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or P carotene. We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.
引用
收藏
页码:362 / 365
页数:4
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