Chemopreventive and therapeutic effects of curcumin

被引：686

作者：

Duvoix, A ^{[1
]}

Blasius, R ^{[1
]}

Delhalle, S ^{[1
]}

Schnekenburger, M ^{[1
]}

Morceau, F ^{[1
]}

Henry, E ^{[1
]}

Dicato, M ^{[1
]}

Diederich, M ^{[1
]}

机构：

[1] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg

来源：

CANCER LETTERS | 2005年 / 223卷 / 02期

关键词：

chemopreventive agent; curcumin; cancer; apoptosis; drug metabolism;

D O I：

10.1016/j.canlet.2004.09.041

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. Curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. In this review, we describe both properties and mode of action of curcumin on carcinogenesis, gene expression mechanisms and drug metabolism. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：181 / 190

页数：10

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