Mutational escape from CD8+ T cell immunity:: HCV evolution, from chimpanzees to man

被引：161

作者：

Bowen, DG

Walker, CM ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43210 USA

[2] Columbus Childrens Res Inst, Ctr Vaccines & Immun, Columbus, OH 43205 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 11期

关键词：

D O I：

10.1084/jem.20050808

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.

引用

页码：1709 / 1714

页数：6

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