The main HTLV-I-harboring cells in the muscles of viral carriers with polymyositis are not macrophages but CD4(+) lymphocytes

被引：16

作者：

Higuchi, I ^{[1
]}

Hashimoto, K ^{[1
]}

Matsuoka, E ^{[1
]}

Rosales, R ^{[1
]}

Nakagawa, M ^{[1
]}

Arimura, K ^{[1
]}

Izumo, S ^{[1
]}

Osame, M ^{[1
]}

机构：

[1] KAGOSHIMA UNIV,FAC MED,CTR CHRON VIRAL DIS,KAGOSHIMA 890,JAPAN

来源：

ACTA NEUROPATHOLOGICA | 1996年 / 92卷 / 04期

关键词：

in situ polymerase chain reaction; immunohistochemistry; human T cell lymphotropic virus type I; proviral DNA; polymyositis;

D O I：

10.1007/s004010050530

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have analyzed muscle biopsy specimens from polymyositis patients who are also positive for human T cell lymphotropic virus type I ((HTLV-I) using both immunohistochemistry for surface antigens of lymphocytes and macrophages and in situ polymerase chain reaction for HTLV-I proviral DNA on the same sections. We found HTLV-I in CD4(+) cells but not in macrophages. This finding suggests that most of the HTLV-I-containing CD4(+) cells are not macrophages but lymphocytes.

引用

页码：358 / 361

页数：4

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