Current strategies for subunit and genetic viral veterinary vaccine development

被引：82

作者：

Brun, Alejandro ^{[1
]}

Barcena, Juan ^{[1
]}

Blanco, Esther ^{[1
]}

Borrego, Belen ^{[1
]}

Dory, Daniel ^{[2
]}

Escribano, Jose M. ^{[3
]}

Le Gall-Recule, Ghislaine ^{[2
]}

Ortego, Javier ^{[1
]}

Dixon, Linda K. ^{[4
]}

机构：

[1] INIA, Ctr Invest Sanidad Anim, Madrid 28130, Spain

[2] Agence Natl Secur Sanit Alimentat Environm & Trav, F-22440 Ploufragan, France

[3] INIA, Dept Biotecnol, Madrid 28040, Spain

[4] Inst Anim Hlth, Pirbright GU24 ONF, England

来源：

VIRUS RESEARCH | 2011年 / 157卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Veterinary vaccines; DNA vaccines; Subunit vaccines; VIRUS-LIKE PARTICLES; MOUTH-DISEASE VIRUS; CLASSICAL SWINE-FEVER; RABBIT HEMORRHAGIC-DISEASE; INFLUENZA-A VIRUS; T-CELL RESPONSES; PROTECTIVE IMMUNE-RESPONSE; B SURFACE-ANTIGEN; HEPATITIS-C VIRUS; LEPIDOPTERAN INSECT CELLS;

D O I：

10.1016/j.virusres.2011.02.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Developing vaccines for livestock provides researchers with the opportunity to perform efficacy testing in the natural hosts. This enables the evaluation of different strategies, including definition of effective antigens or antigen combinations, and improvement in delivery systems for target antigens so that protective immune responses can be modulated or potentiated. An impressive amount of knowledge has been generated in recent years on vaccine strategies and consequently a wide variety of antigen delivery systems is now available for vaccine research. This paper reviews several antigen production and delivery strategies other than those based on the use of live viral vectors. Genetic and protein subunit vaccines as well as alternative production systems are considered in this review. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 12

页数：12

共 224 条

[1]

Self-Assembly of the Recombinant Capsid Protein of a Swine Norovirus into Virus-Like Particles and Evaluation of Monoclonal Antibodies Cross-Reactive with a Human Strain from Genogroup II [J].