Biology of cord blood cells and future prospects for enhanced clinical benefit

被引:48
作者
Broxmeyer, HE [1 ]
机构
[1] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA
[3] Walther Canc Inst, Indianapolis, IN 46208 USA
关键词
cord blood; hematopoietic stem and progenitor cells; mesenchymal stem cells; endothelial progenitor cells; immune cells;
D O I
10.1080/14653240510027190
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Cord blood (CB) has served as a clinically beneficial source of hematopoietic stem (HSC) and progenitor (HPC) cells for transplantation and correction of a large number of malignant and nonmalignant disorders. The capacity of CB to perform these functions is intimately related to the quality and quantity of HSC and HPC present in CB. This review covers the biology of HSC and HPC, efforts to expand these cells ex vivo for enhanced clinical utility that has thus far not been very successful, and recent studies on attempts to enhance the homing and engrafting capability of HSC as an alternative means for more effective use of the limited numbers of CB cells collected. This review also highlights the presence in CB of mesenchymal stem cells, unrestricted somatic stem cells, endothelial progenitor cells and immune cells. The presence and biology of these non-HSC/HPC may open up future possibilities for additional clinical benefit of CB, a product considered mainly for discard before its clinical transplantation potential was realized in the late 1980s.
引用
收藏
页码:209 / 218
页数:10
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