Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells

被引：69

作者：

Schaefer, G ^{[1
]}

Venkataraman, C ^{[1
]}

Schindler, U ^{[1
]}

机构：

[1] Tularik Inc, S San Francisco, CA 94080 USA

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 10期

关键词：

D O I：

10.4049/jimmunol.166.10.5859

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th cell subsets, namely Th1 and Th2 cells, play an important role in mounting an immune response against invading pathogens. Several genes are selectively up-regulated during differentiation and effector phases of Th subsets. In this study, we report the identification of a novel cytokine-like molecule designated FISP (IL-4-induced secreted protein), which is selectively expressed and secreted by Th2 cells. Detectable levels of FISP are observed only 3 days after initiation of Th2 differentiation. Expression of FISP in developing Th cells requires at least two signals: TCR signaling involving protein kinase C activation and STATE-dependent IL-4R signaling.

引用

页码：5859 / 5863

页数：5

共 18 条

[11] The IL-4 receptor: Signaling mechanisms and biologic functions [J].