Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles:: diverse SnarHH reactions, cytotoxicity and spectral behavior

被引：19

作者：

Liu, FY

Xiao, Y

Qian, XH

Zhang, ZC

Cui, JN

Zhang, R

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

TETRAHEDRON | 2005年 / 61卷 / 47期

基金：

中国国家自然科学基金;

关键词：

SNArH reaction; nucleophiles; acenaphtho-heterocycles;

D O I：

10.1016/j.tet.2005.08.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diverse reactivity of highly electron-deficient 8-oxo-8H-acenaphtho[1,2-b]pyrrol-9-carbonitrile I is attractive for the preparation of derivatives bearing different substituents via SNArH reaction with N, O, S nucleophiles. These derivatives were versatile, possessing potential antitumor activities and displaying tunable fluorescence spectral behavior. (c) 2005 Published by Elsevier Ltd.

引用

页码：11264 / 11269

页数：6

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