Continuous flow spectrophotometric determination of paracetamol in pharmaceuticals following continuous microwave assisted alkaline hydrolysis

被引：53

作者：

Criado, A ^{[1
]}

Cárdenas, S ^{[1
]}

Gallego, M ^{[1
]}

Valcárcel, M ^{[1
]}

机构：

[1] Univ Cordoba, Div Analyt Chem, E-14071 Cordoba, Spain

来源：

TALANTA | 2000年 / 53卷 / 02期

关键词：

paracetamol; microwave assisted alkaline hydrolysis; spectrophotometry;

D O I：

10.1016/S0039-9140(00)00509-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper reports a continuous flow-based spectrophotometric method for the determination of paracetamol in pharmaceuticals. Dilute samples containing paracetamol are continuously hydrolysed in an alkaline medium, using a household microwave oven, to p-aminophenol, which reacts with o-cresol in 3.5 M NaOH. The blue derivative thus formed exhibits an absorbance maximum at 620 nm. The detection limit of the method is 0.2 mug ml(-1) and the system obeys Beer's law from 0.6 to 20 mug ml(-1). Repeatability was checked by calculating the R.S.D. for 11 standard solutions containing a paracetamol concentration of 4 mug ml(-1) each and found to be 1.8%. The proposed method was validated by determining paracetamol in various pharmaceutical preparations with average R.S.D. of 2.4%. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：417 / 423

页数：7

共 20 条

[1] Flow injection spectrophotometric determination of paracetamol in pharmaceuticals by means of on-line microwave-assisted hydrolysis and reaction with 8-hydroxyquinoline (8-quinolinol) [J].