Structural differences between HLA-DQ molecules associated with myasthenia gravis characterized by molecular modeling

被引：12

作者：

Hjelmström, P

DeWeese-Scott, C

Penzotti, JE

Lybrand, TP

Sanjeevi, CB ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Hosp, Dept Mol Med, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Karolinska Hosp, Dept Med, S-17176 Stockholm, Sweden

[3] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 85卷 / 01期

关键词：

myasthenia gravis; HLA-DQ; molecular modeling;

D O I：

10.1016/S0165-5728(97)00266-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myasthenia gravis (MG) is characterized by muscle weakness due to autoimmunity against the nicotinic acetylcholine receptor (nAChR). MG is associated with polymorphisms in HLA-DQ genes and the aim of the present study was to characterize structural differences in the peptide binding groove of HLA-DQ molecules positively and negatively associated with MG. Three dimensional models of the positively associated DQ2 (DQB1*02) and negatively associated DQ6 (DQB1*O603) molecules were constructed by homology modeling techniques. The differences in peptide binding properties were primarily localized to peptide-anchor pockets P7 and P9, which might be of importance for the binding of disease-associated peptides from the nAChR. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：102 / 105

页数：4

共 20 条

[1] Characterization of a novel reverse-orientation model for a peptide/MHC complex putatively associated with type I diabetes mellitus [J].