Serum-mediated recognition of liposomes by phagocytic cells of the reticuloendothelial system - The concept of tissue specificity

被引：193

作者：

Moghimi, SM

Patel, HM

机构：

[1] Univ Brighton, Sch Pharm, Brighton BN2 4GJ, E Sussex, England

[2] MicroTek Syst Consultancy Serv Drug Delivery Syst, Nottingham NG7 1EE, England

[3] Sandol, Stanmore HA7 3LF, Middx, England

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 32卷 / 1-2期

关键词：

liposome; liver; macrophage; opsonin; opsono-phagocytosis; reticuloendothelial system; spleen;

D O I：

10.1016/S0169-409X(97)00131-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanisms responsible for the clearance and recognition of intravenously injected liposomes by phagocytic cells of the reticuloendothelial system are presently not well understood. Here, we address a multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation. Emphasis is particularly drawn towards the concept of liposome-blood protein interaction and its role in liposome recognition by various phagocytes of the reticuloendothelial system. (C) 1998 Elsevier Science B.V.

引用

页码：45 / 60

页数：16

共 102 条

[21] LIPOSOME FORMULATIONS WITH PROLONGED CIRCULATION TIME IN BLOOD AND ENHANCED UPTAKE BY TUMORS [J].