Dendritic epidermal T-cell activation

被引：25

作者：

Sharp, LL ^{[1
]}

Jameson, JM ^{[1
]}

Witherden, DA ^{[1
]}

Komori, HK ^{[1
]}

Havran, WL ^{[1
]}

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2005年 / 25卷 / 01期

关键词：

V gamma 3; tissue-resident; intraepithelial lymphocyte;

D O I：

10.1615/CritRevImmunol.v25.i1.10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although gamma delta T cells compose a small proportion of lymphocytes in lymphoid compartments and peripheral blood, they are the major T-cell population present in epithelial tissues. However, the role played by gamma delta TCR expressing intraepithelial lymphocytes (IEL) has been enigmatic. The location of tissue-resident IEL suggests that they are important members of the first line of defense against insult for organs exposed to the environment, including the skin, gut, lungs, and reproductive system. Dendritic epidermal T cells (DETC) are the skin-resident gamma delta IEL and serve as a model system for gamma delta IEL in other locations. DETC have demonstrated importance in the modulation of immune responses, surveillance and repair of tissue, and resistance to infection. This work discusses recent developments in understanding DETC activation.

引用

页码：1 / 17

页数：17

共 139 条

[61] The TCR δ repertoire in normal human skin is restricted and distinct from the TCR δ repertoire in the peripheral blood [J].