Preparation of Ethynylpyridine Macrocycles by Oxidative Coupling of an Ethynylpyridine Trimer with Terminal Acetylenes

被引：17

作者：

Abe, Hajime ^{[1
]}

Kurokawa, Hiroyuki ^{[1
]}

Chida, Yusuke ^{[1
]}

Inouye, Masahiko ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Pharmaceut Sci, Toyama 9300194, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 01期

关键词：

SYNTHETIC LECTIN; MOLECULAR RECOGNITION; RECEPTORS; OLIGOMERS; ASSOCIATION; LIGANDS;

D O I：

10.1021/jo101921e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Macrocycles consisted of pyridine rings and acetylene bonds were prepared by Eglinton coupling from a tandem precursor bearing two terminal alkynyl groups. The composition of molecular size in the cyclized products changed by the reaction solvent. In pyridine, 9-meric and bigger macrocycles were obtained, while that of 6-mer was not. On the other hand, in pyridine/THF mixed solvent, the 6-mer was obtained as a major product.

引用

页码：309 / 311

页数：3

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