Parallel-stranded hairpins containing 8-aminopurines.: Novel efficient probes for triple-helix formation

被引：13

作者：

Aviñó, A

Morales, JC

Frieden, M

de la Torre, BG

García, RG

Cubero, E

Luque, FJ

Orozco, M

Azorín, F

Eritja, R

机构：

[1] Cygene Spain SL, E-08028 Barcelona, Spain

[2] CSIC, Inst Mol Biol, E-08034 Barcelona, Spain

[3] Univ Barcelona, E-08028 Barcelona, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)00295-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure, (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1761 / 1763

页数：3