An enantioselective approach to bis-α-amino acids

被引：41

作者：

Lygo, B ^{[1
]}

Crosby, J

Peterson, JA

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] AstraZeneca, Proc R&D, Macclesfield SK10 2NA, Cheshire, England

[3] Univ Salford, Dept Chem, Salford M5 4WT, Lancs, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 30期

关键词：

alpha-amino acid; asymmetric catalysis; enatioselective alkylation; phase-transfer catalysis;

D O I：

10.1016/S0040-4020(01)00536-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we describe details of a study into the asymmetric synthesis of bis-alpha -amino acids via alkylation of a benzophenone-derived glycine imine under phase-transfer conditions. By employing chiral quaternary ammonium salts derived from cinchona alkaloids it was found that the target bis-amino acids can be produced in good overall yield, and with high levels of stereoselectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6447 / 6453

页数：7

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