A practical asymmetric synthesis of α-methyl α-amino acids using a chiral Cu-salen complex as a phase transfer catalyst

被引：76

作者：

Belokon', YN

Davies, RG

North, M ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

[2] AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 37期

基金：

英国工程与自然科学研究理事会;

关键词：

phase transfer; catalysis; copper; asymmetric synthesis; amino acid;

D O I：

10.1016/S0040-4039(00)01247-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric C-alkylation of N-benzylidene alanine methyl ester has been achieved using a copper(II) (salen) complex as an asymmetric phase transfer catalyst and provides a practical synthesis of alpha-methyl alpha-amino acids with up to 86% enantiomeric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7245 / 7248

页数：4

共 33 条

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