LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients

被引：9

作者：

Chan, Daniel Kam Yin ^{[1
,2
]}

Ng, Ping Wing ^{[3
]}

Mok, Vincent ^{[4
]}

Yeung, Jonas ^{[5
]}

Fang, Zhi Ming ^{[6
]}

Clarke, Raymond ^{[6
]}

Leung, Edward ^{[3
]}

Wong, Lawrence ^{[4
]}

机构：

[1] Bankstown Lidcombe Hosp, Dept Aged Care & Rehabil, Bankstown, NSW 2200, Australia

[2] Univ New S Wales, Fac Med, Kensington, NSW 2033, Australia

[3] United Christian Hosp, Dept Med & Geriatr, Hong Kong, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Div Neurol, Hong Kong, Hong Kong, Peoples R China

[5] AHML Nethersole Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China

[6] St George Hosp, Canc Care Ctr, Kogarah, NSW, Australia

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 09期

关键词：

early-onset Parkinson's disease; LRRK2 Gly2385Arg mutation; Chinese;

D O I：

10.1007/s00702-008-0065-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age <= 45 years) Parkinson's disease was identified and compared with late-onset patients (age > 50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.

引用

页码：1275 / 1277

页数：3

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