The LRRK2 I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson's disease

被引：69

作者：

Lu, CS

Simons, EJ

Wu-Chòu, YH

Di Fonzo, A

Chang, HC

Chen, RS

Weng, YH

Rohé, CF

Breedveld, GJ

Hattori, N

Gasser, T

Oostra, BA

Bonifati, V

机构：

[1] Chang Gung Mem Hosp, Neurosci Res Ctr, Taipei, Taiwan

[2] Chang Gung Mem Hosp, Dept Neurol, Taipei, Taiwan

[3] Chang Gung Mem Hosp, Human Mol Genet Lab, Taipei, Taiwan

[4] Erasmus MC Rotterdam, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

[5] Univ Milan, Ctr Dino Ferrari, Dept Neurol Sci, Milan, Italy

[6] Fdn Osped Maggiore Policlin, Milan, Italy

[7] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 113, Japan

[8] Univ Tubingen, Dept Neurodegenerat Dis, Hertie Inst Clin Brain Res, D-72074 Tubingen, Germany

[9] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy

来源：

PARKINSONISM & RELATED DISORDERS | 2005年 / 11卷 / 08期

关键词：

D O I：

10.1016/j.parkreldis.2005.09.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：521 / 522

页数：2

共 10 条

[1]

Di Fonzo A, 2005, LANCET, V365, P412

[2] An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family [J].

Funayama, M ;

Hasegawa, K ;

Ohta, E ;

Kawashima, N ;

Komiyama, M ;

Kowa, H ;

Tsuji, S ;

Obata, F .

ANNALS OF NEUROLOGY, 2005, 57 (06) :918-921

[3] Common LRRK2 mutation in idiopathic Parkinson's disease [J].

Gilks, WP ;

Abou-Sleiman, PM ;

Gandhi, S ;

Jain, S ;

Singleton, A ;

Lees, AJ ;

Shaw, K ;

Bhatia, KP ;

Bonifati, V ;

Quinn, NP ;

Lynch, J ;

Healy, DG ;

Holton, JL ;

Revesz, T ;

Wood, NW .

LANCET, 2005, 365 (9457) :415-416

[4]

GOLDWURM S, IN PRESS J MED GENET

[5] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[6] Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism:: Evidence of a common founder across European populations [J].

Kachergus, J ;

Mata, IF ;

Hulihan, M ;

Taylor, JP ;

Lincoln, S ;

Aasly, J ;

Gibson, JM ;

Ross, OA ;

Lynch, T ;

Wiley, J ;

Payami, H ;

Nutt, J ;

Maraganore, DM ;

Czyzewski, K ;

Styczynska, M ;

Wszolek, ZK ;

Farrer, MJ ;

Toft, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) :672-680

[7] LRRK2 haplotype analyses in European and North African families with Parkinson disease:: A common founder for the G2019S mutation dating from the 13th century [J].

Lesage, S ;

Leutenegger, AL ;

Ibanez, P ;

Janin, S ;

Lohmann, E ;

Dürr, A ;

Brice, A .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (02) :330-332

[8] Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease [J].

Paisán-Ruíz, C ;

Jain, S ;

Evans, EW ;

Gilks, WP ;

Simón, J ;

van der Brug, M ;

de Munain, AL ;

Aparicio, S ;

Gil, AM ;

Khan, N ;

Johnson, J ;

Martinez, JR ;

Nicholl, D ;

Carrera, IM ;

Pena, AS ;

de Silva, R ;

Lees, A ;

Martí-Massó, JF ;

Pérez-Tur, J ;

Wood, NW ;

Singleton, AB .

NEURON, 2004, 44 (04) :595-600

[9] The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients [J].

Tan, EK ;

Shen, H ;

Tan, LCS ;

Farrer, A ;

Yew, K ;

Chua, E ;

Jamora, RD ;

Puvan, K ;

Puong, KY ;

Zhao, Y ;

Pavanni, R ;

Wong, MC ;

Yih, Y ;

Skipper, L ;

Liu, JJ .

NEUROSCIENCE LETTERS, 2005, 384 (03) :327-329

[10] Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology [J].

Zimprich, A ;

Biskup, S ;

Leitner, P ;

Lichtner, P ;

Farrer, M ;

Lincoln, S ;

Kachergus, J ;

Hulihan, M ;

Uitti, RJ ;

Calne, DB ;

Stoessl, AJ ;

Pfeiffer, RF ;

Patenge, N ;

Carbajal, IC ;

Vieregge, P ;

Asmus, F ;

Müller-Myhsok, B ;

Dickson, DW ;

Meitinger, T ;

Strom, TM ;

Wszolek, ZK ;

Gasser, T .

NEURON, 2004, 44 (04) :601-607

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