Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages

被引：9

作者：

Santucci, MB

Ciaramella, A

Mattei, M

Sumerska, T

Fraziano, M

机构：

[1] Univ Roma Tor Vergata, Dept Biol, Lab Immunol & Mol Pathol, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, NSTA, Rome, Italy

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2003年 / 3卷 / 12期

关键词：

apoptosis; MTB infection; metalloproteinases; monocytes/macrophages; TNF-alpha;

D O I：

10.1016/S1567-5769(03)00202-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis and the downmodulation of membrane CD 14 expression. Moreover, the addition of broad spectrum matrix metalloproteinase inhibitor to cell culture, during MTB infection, decreases the release of soluble TNF-alpha and leads to a simultaneous increase of membrane TNF-alpha. These results show that MTB-induced apoptosis in macrophages is reduced by a MMP inhibitor and most probably is related to TNF-alpha release. This identifies BB-94 as a simultaneous anti-apoptotic and anti-inflammatory molecule during MTB infection. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：1657 / 1665

页数：9

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