Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

被引:234
作者
Scolding, N
Franklin, R
Stevens, S
Heldin, CH
Compston, A
Newcombe, J
机构
[1] MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2SR, England
[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 1TN, England
[3] Univ Cambridge, Dept Vet Med, Cambridge CB2 1TN, England
[4] Inst Neurol, Multiple Sclerosis Lab, London WC1N 3BG, England
[5] Ludwig Inst Canc Res, S-75124 Uppsala, Sweden
关键词
human oligodendrocyte progenitor; remyelination; multiple sclerosis; PDGF-alpha receptor;
D O I
10.1093/brain/121.12.2221
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In multiple sclerosis, partial remyelination is conspicuous in many lesions, but widespread and lasting myelin repair ultimately fails as disability and handicap accumulate. Thus far, the precise identity of the cell responsible for limited spontaneous myelin repair has remained obscure. In the rodent, the proliferative oligodendrocyte progenitor is the most efficient remyelinating cell; this has now been identified in cultures prepared from normal human brain, but has proved difficult to demonstrate in situ. We adapted techniques using antibodies against the human platelet-derived growth factor-a receptor to identify oligodendrocyte progenitors in human tissue sections. Small numbers of oligodendrocyte progenitors were found in normal adult human white matter. Progenitors were also demonstrable in acute and chronic lesions from patients dying with multiple sclerosis, but with no evidence of any marked reactive increase in cell numbers. Understanding the biology of the remyelinating cell, and in particular the reason for its apparent failure to repopulate demyelinated lesions, is important for the development of remyelination treatments.
引用
收藏
页码:2221 / 2228
页数:8
相关论文
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