Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q

被引：32

作者：

Scherer, SW

Duvoisin, RM

Kuhn, R

Heng, HHQ

Belloni, E

Tsui, LC

机构：

[1] HOSP SICK CHILDREN,DEPT GENET,TORONTO,ON M5G 1X8,CANADA

[2] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON,CANADA

[3] CORNELL UNIV,COLL MED,DYSON VIS RES INST,NEW YORK,NY

[4] CIBA GEIGY AG,DIV PHARMACEUT,CNS RES,CH-4002 BASEL,SWITZERLAND

来源：

GENOMICS | 1996年 / 31卷 / 02期

关键词：

D O I：

10.1006/geno.1996.0036

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messsenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7. (C) 1996 Academic Press, Inc.

引用

页码：230 / 233

页数：4

共 20 条

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