β-lactones as privileged structures for the active-site labeling of versatile bacterial

被引：139

作者：

Boettcher, Thomas ^{[1
]}

Sieber, Stephan A. ^{[1
]}

机构：

[1] Univ Munich, CIPSM, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 24期

关键词：

biomimetic synthesis; enzymes; lactones; medicinal chemistry; proteomics;

D O I：

10.1002/anie.200705768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A chemical proteomic strategy has been applied directly to bacterial proteomes, and b-lactones have been identified as important natural product derivatives with a high affinity to various enzyme classes (see picture). This approach may serve as a potent tool for the identification of novel antibacterial targets, the study of their function, and the definition of novel lead structures for the design of enzyme inhibitors. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4600 / 4603

页数：4

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