A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA

被引：36

作者：

Choi, S ^{[1
]}

Delaney, S ^{[1
]}

Orbai, L ^{[1
]}

Padgett, EJ ^{[1
]}

Hakemian, AS ^{[1
]}

机构：

[1] Middlebury Coll, Dept Chem & Biochem, Middlebury, VT 05753 USA

来源：

INORGANIC CHEMISTRY | 2001年 / 40卷 / 22期

关键词：

D O I：

10.1021/ic015549t

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A platinum(IV) complex with a high reduction potential, d,l-1,2-diaminocyclohexyltetrachloroplatinum(IV) (Pt-IV(dach)Cl-4), oxidizes guanine in guanosine-5'-monophosphate (GMP), 2'-deoxyguanosine-5'-monophosphate (dGMP), d(GG), and a double-stranded oligonucleotide to 8-oxoguanine. To the best of our knowledge, this is the first report that provides unambiguous evidence of DNA oxidation by a Pt-IV complex. This oxidative damage may differentiate the anticancer activity of Pt-IV complexes from their Pt-II analogues.

引用

页码：5481 / +

页数：3

共 9 条

[1] High-intensity UV laser photolysis of DNA and purine 2'-deoxyribonucleosides: Formation of 8-oxopurine damage and oligonucleotide strand cleavage as revealed by HPLC and gel electrophoresis studies [J].

Angelov, D ;

Spassky, A ;

Berger, M ;

Cadet, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (47) :11373-11380

[2] A long-lived ascorbate radical in the platinum(II) catalysed reductions of platinum(IV) antitumor drugs [J].

Bose, RN ;

Weaver, EL .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1997, (11) :1797-1799

[3] Oxidative nucleobase modifications leading to strand scission [J].

Burrows, CJ ;

Muller, JG .

CHEMICAL REVIEWS, 1998, 98 (03) :1109-1151

[4]

CARIEPPY KC, 1989, J AM CHEM SOC, V111, P4947

[5] Substitution and reduction of platinum(IV) complexes by a nucleotide, guanosine 5′-monophosphate [J].

Choi, S ;

Mahalingaiah, S ;

Delaney, S ;

Neale, NR ;

Masood, S .

INORGANIC CHEMISTRY, 1999, 38 (08) :1800-1805

[6] Reduction and anticancer activity of platinum(IV) complexes [J].

Choi, S ;

Filotto, C ;

Bisanzo, M ;

Delaney, S ;

Lagasee, D ;

Whitworth, JL ;

Jusko, A ;

Li, CR ;

Wood, NA ;

Willingham, J ;

Schwenker, A ;

Spaulding, K .

INORGANIC CHEMISTRY, 1998, 37 (10) :2500-2504

[7] Platinum(II) complexes catalyze reactions between platinum(IV) complexes and 9-methylxanthine [J].

Roat, RM ;

Jerardi, MJ ;

Kopay, CB ;

Heath, DC ;

Clark, JA ;

DeMars, JA ;

Weaver, JM ;

Bezemer, E ;

Reedijk, J .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1997, (19) :3615-3621

[8] How easily oxidizable is DNA? One-electron reduction potentials of adenosine and guanosine radicals in aqueous solution [J].

Steenken, S ;

Jovanovic, SV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (03) :617-618

[9] Efficient oxidation of 2′-deoxyguanosine by Mn-TMPyP/KHSO5 to imidazolone dIz without formation of 8-oxo-dG [J].

Vialas, C ;

Pratviel, G ;

Claparols, C ;

Meunier, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (45) :11548-11553

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