Progress towards synthetic enzymes for phosphoester hydrolysis

被引：153

作者：

Komiyama, M ^{[1
]}

Sumaoka, J ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Tokyo 1138656, Japan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 06期

关键词：

D O I：

10.1016/S1367-5931(98)80113-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis of artificial enzymes for catalyzing phosphoester hydrolysis has been attracting interest for a long time. The remarkable discovery that lanthanide ions catalyze the hydrolysis of DNA and RNA spurred the trend. Currently, progress is being made, mainly in the preparation of homogeneous catalysts, the promotion of catalytic activity by using acid/base cooperation within catalysts, the detailed understanding of the reaction mechanisms involved, and the design of artificial enzymes expressing high specificity and catalytic turn-over.

引用

页码：751 / 757

页数：7

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