Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFNα:: results from the Primoferon A (ANRS 086) Study

被引：46

作者：

Emilie, D ^{[1
]}

Burgard, M

Lascoux-Combe, C

Laughlin, M

Krzysiek, R

Pignon, C

Rudent, A

Molina, JM

Livrozet, JM

Souala, F

Chene, G

Grangeot-Keros, L

Galanaud, P

Sereni, D

Rouzioux, C

机构：

[1] Inst Paris Sud Cytokines, Hop Antoine Beclere, Serv Med Interne & Immunol Clin, Clamart, France

[2] Inst Paris Sud Cytokines, Hop Antoine Beclere, Serv Microbiol Immunol, Clamart, France

[3] CHU Necker Enfants Malad, Virol Lab, Paris, France

[4] Hop St Louis, Serv Med Interne, Paris, France

[5] Hop St Louis, Serv Malad Infect, Paris, France

[6] Schering Plough Res Inst, Kenilworth, NJ USA

[7] Hop Edouard Herriot, Serv Med Transplantat & Immunol, Lyon, France

[8] Hop Pontchaillou, Serv Malad Infect, Rennes, France

[9] INSERM, U330, Bordeaux, France

来源：

AIDS | 2001年 / 15卷 / 11期

关键词：

D O I：

10.1097/00002030-200107270-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IFN alpha has both antiviral and immunostimulating properties. The ANRS086 Primoferon A Study evaluated, in 12 patients with primary HIV infection the tolerance and efficacy of an early and transient administration of pegylated IFN alpha, in addition to highly active antiretroviral therapy. Tolerance was good, and this regimen allowed the early control of HIV replication and rapid decay of the viral reservoir. These results support the initiation of comparative studies with pegylated IFN alpha in primary HIV infection.

引用

页码：1435 / 1437

页数：3

共 25 条

[21] Detection of low HIV-1 RNA levels in plasma [J].

Schockmel, GA ;

Yerly, S ;

Perrin, L .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1997, 14 (02) :179-183

[22] Virological and immunological effects of combination antiretroviral therapy with zidovudine, lamivudine, and indinavir during primary human immunodeficiency virus type 1 infection [J].

Smith, DM ;

Berrey, MM ;

Robertson, M ;

Mehrotra, D ;

Markowitz, M ;

Perrin, L ;

Clumeck, N ;

Lazzarin, A ;

Burckhardt, B ;

Weber, R ;

Corey, L ;

Cooper, DA .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (03) :950-954

[23] MOLECULAR-CLONING OF A NEW INTERFERON-INDUCED FACTOR THAT REPRESSES HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT EXPRESSION [J].

TISSOT, C ;

MECHTI, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (25) :14891-14898

[24] Induction of bystander T cell proliferation by viruses and type I interferon in vivo [J].

Tough, DF ;

Borrow, P ;

Sprent, J .

SCIENCE, 1996, 272 (5270) :1947-1950

[25] Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: Partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia [J].

Zaunders, JJ ;

Cunningham, PH ;

Kelleher, AD ;

Kaufmann, GR ;

Jaramillo, AB ;

Wright, R ;

Smith, D ;

Grey, P ;

Vizzard, J ;

Carr, A ;

Cooper, DA .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (02) :320-329

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