IgG, IgA and IgM antibodies against FSH:: Serological markers of pathogenic autoimmunity or of normal immunoregulation?

被引:29
作者
Haller, K
Mathieu, C
Rull, K
Matt, K
Béne, MC
Uibo, R
机构
[1] Univ Tartu, Dept Immunol, Inst Gen & Mol Pathol, EE-50090 Tartu, Estonia
[2] Univ Tartu, Ctr Mol & Clin Med, EE-50090 Tartu, Estonia
[3] CHU, Immunol Lab, Fac Med, Vandoeuvre Les Nancy, France
[4] Univ Tartu, Dept Obstet & Gynaecol, EE-50090 Tartu, Estonia
关键词
autoimmunity; follicle-stimulating hormone; infertility; pregnancy;
D O I
10.1111/j.1600-0897.2005.00306.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Problem Autoimmune mechanisms are often involved in causing infertility. Among the possible targets of autoantibodies, the follicle-stimulating which regulates the follicular maturation in human hormone (FSH). ovary is a promising candidate. We aimed to study whether anti-FSH-antibodies might be involved in different clinical types of infertility. Method of study The study group consisted of 178 patients (75 with polycystic ovary syndrome (PCOS), 103 with endometriosis) and 75 pregnant women. Female blood donors formed the control group (n = 85). Indirect enzyme-linked immunosorbent assay tests were performed using purified FSH as antigens and a synthetic peptide corresponding to the 78-93 region (V14D) of the human FSH beta-chain. Conclusion We showed that anti-FSH-antibodies were present in controls and their production decreased during pregnancy. Endometriosis and PCOS were associated with higher values of anti-FSH-immunoglobulin (Ig)A, anti-V14D-IgA, and endometriosis with anti-V14D-IgG. Our data suggest that anti-FSH-IgA could be a marker of ovarian disorders that cause infertility.
引用
收藏
页码:262 / 269
页数:8
相关论文
共 46 条
[1]  
BARBARINOMONNIER P, 1991, FERTIL STERIL, V56, P928
[2]  
Canis M, 1997, FERTIL STERIL, V67, P817
[3]   Clinical manifestations of genetic defects affecting gonadotrophins and their receptors [J].
Conway, GS .
CLINICAL ENDOCRINOLOGY, 1996, 45 (06) :657-663
[4]   HYPERANDROGENIC ANOVULATION (PCOS) - A UNIQUE DISORDER OF INSULIN ACTION ASSOCIATED WITH AN INCREASED RISK OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
DUNAIF, A .
AMERICAN JOURNAL OF MEDICINE, 1995, 98 :S33-S39
[5]  
EROGLU GE, 1994, AM J REPROD IMMUNOL, V31, P1
[6]   Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J].
Fauser, BCJM ;
Chang, J ;
Azziz, R ;
Legro, R ;
Dewailly, D ;
Franks, S ;
Tarlatzis, BC ;
Fauser, B ;
Balen, A ;
Bouchard, P ;
Dahlgren, E ;
Devoto, L ;
Diamanti, E ;
Dunaif, A ;
Filicori, M ;
Homburg, R ;
Ibanez, L ;
Laven, J ;
Magoffin, D ;
Nestler, J ;
Norman, RJ ;
Pasquali, R ;
Pugeat, M ;
Strauss, J ;
Tan, S ;
Taylor, A ;
Wild, R ;
Wild, S ;
Ehrmann, D ;
Lobo, R .
HUMAN REPRODUCTION, 2004, 19 (01) :41-47
[7]   Polycystic ovary syndrome in autoimmune disease [J].
Fénichel, P ;
Gobert, B ;
Carré, Y ;
Barbarino-Monnier, P ;
Hiéronimus, S .
LANCET, 1999, 353 (9171) :2210-2210
[8]  
Ferro VA, 1998, AM J REPROD IMMUNOL, V40, P187
[9]   Autoimmunity and antigenic targets in ovarian pathology [J].
Forges, T ;
Monnier-Barbarino, P ;
Faure, GC ;
Béné, MC .
HUMAN REPRODUCTION UPDATE, 2004, 10 (02) :163-175
[10]   Three-dimensional structure of human follicle-stimulating hormone [J].
Fox, KM ;
Dias, JA ;
Van Roey, P .
MOLECULAR ENDOCRINOLOGY, 2001, 15 (03) :378-389