An improved synthesis of azidothymidine

被引：12

作者：

Balagopala, MI ^{[1
]}

Ollapally, AP ^{[1
]}

Lee, HJ ^{[1
]}

机构：

[1] FLORIDA A&M UNIV,COLL PHARM & PHARMACEUT SCI,TALLAHASSEE,FL 32307

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319608002136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A convenient and high yielding procedure is described for a direct conversion of thymidine (1) into 2,3'-anhydrothymidine (2) using the Mitsunobu reaction. Isolation and characterization of two new compounds, 3 and 4, are discussed. AZT has been synthesized from 1 in two steps, in 62% overall yield, by heating 2 with NaN3 in DMF.

引用

页码：899 / 906

页数：8

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