A SHORT SYNTHESIS OF 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE

被引：15

作者：

COSFORD, NDP

SCHINAZI, RF

机构：

[1] VET AFFAIRS MED CTR,ATLANTA,GA 30033

[2] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319308021201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of sodium metal in HMPA-THF with 2,3'-anhydrothymidine 1a results in an elimination to give the 2',3'-unsaturated nucleoside 3a. This process was utilized in a synthesis of the antiviral drug D4T from thymidine.

引用

页码：149 / 155

页数：7

共 23 条

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