Synthesis of 4-substituted tetrahydropyridines by cross-coupling of enol phosphates

被引：66

作者：

Larsen, US

Martiny, L

Begtrup, M ^{[1
]}

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark

[2] Novo Nordisk AS, Isotope Chem, DK-2760 Malov, Denmark

[3] Riso Natl Lab, Radiat Res Dept, DK-4000 Roskilde, Denmark

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 24期

关键词：

D O I：

10.1016/j.tetlet.2005.03.203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enol phosphates, synthesized from 4-piperidone, react by palladium catalyzed cross-coupling with arylboronic acids and by iron and palladium catalyzed cross-coupling with Grignard reagents to give 4-substituted tetrahydropyridines. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4261 / 4263

页数：3

相关论文

共 31 条

[11] Palladium-catalysed coupling of vinyl phosphates with aryl or heteroaryl boronic acids. Application to the synthesis of substituted nitrogen containing heterocycles [J].

Lepifre, F ;

Buon, C ;

Rabot, R ;

Bouyssou, P ;

Coudert, G .

TETRAHEDRON LETTERS, 1999, 40 (35) :6373-6376

[12] Palladium-catalyzed coupling of vinyl phosphates with aryl or heteroaryl boronic acids. Application to the synthesis of substituted nitrogen containing heterocycles [J].

Lepifre, F ;

Clavier, S ;

Bouyssou, P ;

Coudert, G .

TETRAHEDRON, 2001, 57 (32) :6969-6975

[13] Diversity oriented synthesis and branching reaction pathway to generate natural product-like compounds [J].

Liao, Y ;

Hu, YH ;

Wu, H ;

Zhu, Q ;

Donovan, M ;

Fathi, R ;

Yang, Z .

CURRENT MEDICINAL CHEMISTRY, 2003, 10 (21) :2285-2316

[14]

Littke AF, 2002, ANGEW CHEM INT EDIT, V41, P4176, DOI 10.1002/1521-3773(20021115)41:22<4176::AID-ANIE4176>3.0.CO

[15]

2-U

[16]

Littke AF, 1998, ANGEW CHEM INT EDIT, V37, P3387, DOI 10.1002/(SICI)1521-3773(19981231)37:24<3387::AID-ANIE3387>3.0.CO

[17]

2-P

[18] Preparation and cycloaddition reactions of enantiopure 2-(N-acylamino)-1,3-dienes for the synthesis of octahydroquinoline derivatives [J].

Lo Galbo, F ;

Occhiato, EG ;

Guarna, A ;

Faggi, C .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (16) :6360-6368

[19] Nickel-catalyzed cross-couplings of cyclohexenyl phosphate and arylboronic acids [J].

Nan, Y ;

Yang, Z .

TETRAHEDRON LETTERS, 1999, 40 (17) :3321-3324

[20]

Nicolaou KC, 2001, ANGEW CHEM INT EDIT, V40, P1262, DOI 10.1002/1521-3773(20010401)40:7<1262::AID-ANIE1262>3.0.CO

← 1 2 3 4 →