A novel and effective chiral phosphoramide catalyst for the borane-mediated asymmetric reduction of prochiral α-halo ketones

被引：28

作者：

Basavaiah, D ^{[1
]}

Reddy, GJ ^{[1
]}

Chandrashekar, V ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(01)00101-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The novel chiral phosphoramide, 1,4-bis[(5S)-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo(3.3.0)octan-2-yl]piperazine, was synthesised and successfully employed as a catalyst in the borane-mediated asymmetric reductions of prochiral cc-halo ketones, providing the corresponding a-halo alcohols in 90-95% enantiomeric purities. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：685 / 689

页数：5

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