Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice

被引：52

作者：

Gebre-Medhin, S

Mulder, H

Zhang, YZ

Sundler, F

Betsholtz, C

机构：

[1] Univ Gothenburg, Dept Med Biochem, S-40530 Gothenburg, Sweden

[2] Lund Univ, Dept Physiol & Neurosci, Sect Neuroendocrine Cell Biol, Lund, Sweden

[3] Lund Univ, Dept Cell & Mol Biol, Lund, Sweden

[4] Harvard Inst Med, Boston, MA 02114 USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 63卷 / 01期

关键词：

islet amyloid polypeptide; calcitonin gene-related peptide; substance D; gene knock out; Dorsat root ganglion (DRG) neurons; paw formalin test; adjuvant-induced inflammation;

D O I：

10.1016/S0169-328X(98)00269-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Islet amyloid polypeptide (LAPP or amylin) is predominantly expressed by insulin cells, but occurs also in primary sensory neurons in the rat. Here, using mice targeted for a null mutation in the IAPP gene,we establish murine expression of IAPP in sensory neurons; its distribution in a population of calcitonin gene-related peptide-containing neurons in the spinal cord and dorsal root ganglion is similar to that previously described in the wt. We also report the IAPP mutant mice display a reduced pain response in the paw formalin test. Adjuvant-induced joint inflammation was not altered in LAPP mutants, arguing against a peripheral inflammatory abnormality. These findings lead us to suggest that IAPP has a pro-nociceptive function in primary sensory neurons. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：180 / 183

页数：4