Stem Cell Research in Stroke How Far From the Clinic?

被引：139

作者：

Lindvall, Olle ^{[1
,3
]}

Kokaia, Zaal ^{[2
,3
]}

机构：

[1] Univ Hosp, Lab Neurogenesis & Cell Therapy, Wallenberg Neurosci Ctr, SE-22184 Lund, Sweden

[2] Univ Hosp, Lab Neural Stem Cell Biol & Therapy, SE-22184 Lund, Sweden

[3] Lund Stem Cell Ctr, Lund, Sweden

来源：

STROKE | 2011年 / 42卷 / 08期

基金：

瑞典研究理事会;

关键词：

acute stroke; inflammation; neural stem cell; neurogenesis; neuroregeneration; stem cells; stroke recovery; transplantation; FOCAL CEREBRAL-ISCHEMIA; TRAUMATIC BRAIN-INJURY; STROMAL CELLS; ADULT RATS; ENDOGENOUS NEUROGENESIS; FUNCTIONAL RECOVERY; NEURONAL DIFFERENTIATION; PROVIDE NEUROPROTECTION; FOREBRAIN NEUROGENESIS; THERAPEUTIC BENEFITS;

D O I：

10.1161/STROKEAHA.110.599654

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke. (Stroke. 2011;42:2369-2375.)

引用

页码：2369 / 2375

页数：7

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