On the interpretation of rat carcinogenicity studies for human PTH(1-34) and human PTH(1-84)

被引：26

作者：

Tashjian, Armen H., Jr. ^{[1
,2
]}

Goltzman, David ^{[3
,4
,5
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] McGill Univ, Royal Victoria Hosp, Calcium Res Lab, Montreal, PQ H3A 1A1, Canada

[4] McGill Univ, Royal Victoria Hosp, Dept Med, Montreal, PQ H3A 1A1, Canada

[5] McGill Univ, Royal Victoria Hosp, Dept Physiol, Montreal, PQ H3A 1A1, Canada

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2008年 / 23卷 / 06期

关键词：

D O I：

10.1359/JBMR.080208

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

引用

页码：803 / 811

页数：9

共 29 条

[1]

EXPRESSION CLONING OF A COMMON RECEPTOR FOR PARATHYROID-HORMONE AND PARATHYROID HORMONE-RELATED PEPTIDE FROM RAT OSTEOBLAST-LIKE CELLS - A SINGLE RECEPTOR STIMULATES INTRACELLULAR ACCUMULATION OF BOTH CAMP AND INOSITOL TRISPHOSPHATES AND INCREASES INTRACELLULAR FREE CALCIUM [J].

ABOUSAMRA, AB ;

JUPPNER, H ;

FORCE, T ;

FREEMAN, MW ;

KONG, XF ;

SCHIPANI, E ;

URENA, P ;

RICHARDS, J ;

BONVENTRE, JV ;

POTTS, JT ;

KRONENBERG, HM ;

SEGRE, GV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2732-2736

[2]

BOORMAN GA, 1990, PATHOLOGY FISCHER RA, P209

[3]

Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: Importance in the interpretation of PTH values [J].

Brossard, JH ;

Cloutier, M ;

Roy, L ;

Lepage, R ;

GasconBarre, N ;

DAmour, P .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) :3923-3929

[4]

Human carcinogenic risk evaluation: An alternative approach to the two-year rodent bioassay [J].

Cohen, SM .

TOXICOLOGICAL SCIENCES, 2004, 80 (02) :225-229

[5]

Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals [J].

Contrera, JF ;

Jacobs, AC ;

DeGeorge, JJ .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1997, 25 (02) :130-145

[6]

Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells [J].

Datta, Nabanita S. ;

Pettway, Glenda J. ;

Chen, Chen ;

Koh, Amy J. ;

McCauley, Laurie K. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (07) :951-964

[7]

DELLAPORTA G, 1990, TERATOGEN CARCIN MUT, V10, P137

[8]

Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor [J].

Divieti, P ;

John, MR ;

Jüppner, H ;

Bringhurst, FR .

ENDOCRINOLOGY, 2002, 143 (01) :171-176

[9]

Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells:: Determinants of ligand binding and bioactivity [J].

Divieti, P ;

Geller, AI ;

Suliman, G ;

Jüppner, H ;

Bringhurst, FR .

ENDOCRINOLOGY, 2005, 146 (04) :1863-1870

[10]

Unexpected tumour findings in lifetime rodent bioassay studies - what to do? [J].

Ettlin, RA ;

Prentice, DE .

TOXICOLOGY LETTERS, 2002, 128 (1-3) :17-33

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