Fucoidan: Structure and bioactivity

被引:960
作者
Li, Bo [1 ]
Lu, Fei [1 ]
Wei, Xinjun [1 ]
Zhao, Ruixiang [1 ]
机构
[1] Henan Inst Sci & Technol, Sch Food Sci, Xinxiang 453003, Henan, Peoples R China
来源
MOLECULES | 2008年 / 13卷 / 08期
关键词
fucoidan; structure; bioactivity;
D O I
10.3390/molecules13081671
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fucoidan refers to a type of polysaccharide which contains substantial percentages of L-fucose and sulfate ester groups, mainly derived from brown seaweed. For the past decade fucoidan has been extensively studied due to its numerous interesting biological activities. Recently the search for new drugs has raised interest in fucoidans. In the past few years, several fucoidans' structures have been solved, and many aspects of their biological activity have been elucidated. This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure and bioactivity.
引用
收藏
页码:1671 / 1695
页数:25
相关论文
共 128 条
[1]   Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum [J].
Adhikari, Utpal ;
Mateii, Cecilia G. ;
Chattopadhyay, Kausik ;
Pujol, Carlos A. ;
Damonte, Elsa B. ;
Ray, Bimalendu .
PHYTOCHEMISTRY, 2006, 67 (22) :2474-2482
[2]   Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways [J].
Aisa, Y ;
Miyakawa, Y ;
Nakazato, T ;
Shibata, H ;
Saito, K ;
Ikeda, Y ;
Kizaki, M .
AMERICAN JOURNAL OF HEMATOLOGY, 2005, 78 (01) :7-14
[3]   Heterofucans from Dictyota menstrualis have anticoagulant activity [J].
Albuquerque, IRL ;
Queiroz, KCS ;
Alves, LG ;
Santos, EA ;
Leite, EL ;
Rocha, HAO .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2004, 37 (02) :167-171
[4]   Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga [J].
Alekseyenko, T. V. ;
Zhanayeva, S. Ya. ;
Venediktova, A. A. ;
Zvyagintseva, T. N. ;
Kuznetsova, T. A. ;
Besednova, N. N. ;
Korolenko, T. A. .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 143 (06) :730-732
[5]   Low molecular weight fucan prevents transplant coronaropathy in rat cardiac allograft model [J].
Alkhatib, Bassam ;
Freguin-Bouilland, Caroline ;
Lallemand, Francoise ;
Henry, Jean Paul ;
Litzler, Pierre-Yves ;
Marie, Jean Paul ;
Richard, Vincent ;
Thuillez, Christian ;
Plissonnier, Didier .
TRANSPLANT IMMUNOLOGY, 2006, 16 (01) :14-19
[6]   Ultrastructure of acidic polysaccharides from the cell walls of brown algae [J].
Andrade, LR ;
Salgado, LT ;
Farina, M ;
Pereira, MS ;
Mourao, PAS ;
Filho, GMA .
JOURNAL OF STRUCTURAL BIOLOGY, 2004, 145 (03) :216-225
[7]   ISOLATION AND PURIFICATION OF FUCOIDIN FROM BROWN SEAWEED PELVETIA WRIGHTII [J].
ANNO, K ;
TERAHATA, H ;
HAYASHI, Y ;
SENO, N .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1966, 30 (05) :495-&
[8]   ISOLATION OF L-FUCOSE 4-SULFATE FROM FUCOIDAN [J].
ANNO, K ;
SENO, N ;
OTA, M .
CARBOHYDRATE RESEARCH, 1970, 13 (01) :167-&
[9]   Characterization of a new α-L-fucosidase isolated from the marine mollusk Pecten maximus that catalyzes the hydrolysis of α-L-fucose form algal fucoidan (Ascophyllum nodosum) [J].
Berteau, O ;
McCort, I ;
Goasdoué, N ;
Tissot, B ;
Daniel, R .
GLYCOBIOLOGY, 2002, 12 (04) :273-282
[10]   Structure of a fucoidan from the brown seaweed Fucus serratus L. [J].
Bilan, MI ;
Grachev, AA ;
Shashkov, AS ;
Nifantiev, NE ;
Usov, AI .
CARBOHYDRATE RESEARCH, 2006, 341 (02) :238-245