BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

被引：54

作者：

Nakajima, A ^{[1
]}

Kataoka, K ^{[1
]}

Hong, M ^{[1
]}

Sakaguchi, M ^{[1
]}

Huh, N ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Cell Biol, Okayama 7008558, Japan

来源：

CANCER LETTERS | 2003年 / 201卷 / 02期

关键词：

protein kinase; BRAP2; BRCA1; metastasis;

D O I：

10.1016/S0304-3835(03)00443-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：195 / 201

页数：7

共 17 条

[1]

APLIN JD, 1991, J CELL SCI, V99, P681

[2] Structure and mechanism of DNA topoisomerase II [J].

Berger, JM ;

Gamblin, SJ ;

Harrison, SC ;

Wang, JC .

NATURE, 1996, 379 (6562) :225-232

[3] IMPLANTATION AND THE PLACENTA - KEY PIECES OF THE DEVELOPMENT PUZZLE [J].

CROSS, JC ;

WERB, Z ;

FISHER, SJ .

SCIENCE, 1994, 266 (5190) :1508-1518

[4] Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and carcinomas [J].

Fukuda, S ;

Kuroki, T ;

Kohsaki, H ;

Hayashi, S ;

Ozaki, K ;

Yamori, T ;

Tsuruo, T ;

Nakamori, S ;

Imaoka, S ;

Nakamura, Y .

JAPANESE JOURNAL OF CANCER RESEARCH, 1997, 88 (08) :725-731

[5] PROTEIN KINASES .6. THE EUKARYOTIC PROTEIN-KINASE SUPERFAMILY - KINASE (CATALYTIC) DOMAIN-STRUCTURE AND CLASSIFICATION [J].

HANKS, SK ;

HUNTER, T .

FASEB JOURNAL, 1995, 9 (08) :576-596

[6]

HART IR, 1979, AM J PATHOL, V97, P587

[7]

Hashimoto Y, 1996, CANCER RES, V56, P5266

[8] Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential [J].

Kataoka, K ;

Nakajima, A ;

Takata, Y ;

Saito, S ;

Huh, NH .

CANCER LETTERS, 2001, 163 (02) :213-219

[9] Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs [J].

Li, S ;

Ku, CY ;

Farmer, AK ;

Cong, YS ;

Chen, CF ;

Lee, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (11) :6183-6189

[10] Detecting protein function and protein-protein interactions from genome sequences [J].

Marcotte, EM ;

Pellegrini, M ;

Ng, HL ;

Rice, DW ;

Yeates, TO ;

Eisenberg, D .

SCIENCE, 1999, 285 (5428) :751-753

← 1 2 →