Studies on the spectral-luminescent properties of the novel homodimer styryl dyes in complexes with DNA

被引：10

作者：

Kovalska, VB ^{[1
]}

Kocheshev, IO ^{[1
]}

Kryvorotenko, DV ^{[1
]}

Balanda, A ^{[1
]}

Yarmoluk, SM ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Mol Biol & Genet, UA-03143 Kiev, Ukraine

来源：

JOURNAL OF FLUORESCENCE | 2005年 / 15卷 / 03期

关键词：

nucleic acid; fluorescent probes; homodimer styryl dyes;

D O I：

10.1007/s10895-005-2620-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Series of homodimer styryls containing on (p-dimethylaminostyryl) pyridinium residues that are connected with aliphatic linkage group was synthesized. Spectral luminescent properties of obtained dyes in free state and in nucleic acids presence were studied. It was shown that DNA binding affinity of the novel homodimers exceeds that of parent monomer (p-dimethylaminostyryl)pyridine iodide. For homodimers with the linkage 4-10 carbon atoms preference in binding to DNA than to RNA was observed. It could be concluded that parent monomer has different mechanisms of binding to nucleic acids than corresponding homodimer dye.

引用

页码：215 / 219

页数：5

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