Transcriptional effect of hypoxia on placental leptin

被引：77

作者：

Grosfeld, A

Turban, S

André, J

Cauzac, M

Challier, JC

Mouzon, SH

Guerre-Millo, M

机构：

[1] INSERM, U465, F-75006 Paris, France

[2] CNRS, UPR 1524, Paris, France

[3] Univ Paris 06, UPRES EA 2396, Paris, France

来源：

FEBS LETTERS | 2001年 / 502卷 / 03期

关键词：

placenta; leptin; preeclampsia; hypoxia; BeWo cell; hypoxia-inducible factor-1;

D O I：

10.1016/S0014-5793(01)02673-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We observed recently1 that placental leptin is markedly increased in preeclampsia. Since this disorder is associated with vascular disorders, we have tested the hypothesis that hypoxia regulates leptin expression. We show that hypoxia increased leptin mRNA and secretion in trophoblast-derived BeWo cells. This effect was mediated through leptin promoter activation. 5' deletion analysis allowed us to delineate two regions containing 1.87 kb and 1.20 kb of the promoter which conferred respectively high and low responsiveness to hypoxia. These data indicate that leptin is up-regulated by hypoxia through a transcriptional mechanism likely to involve distinct hypoxia-responsive cis-acting sequences on the promoter. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：122 / 126

页数：5

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