Peripheral blood phagocyte CD14 and CD11b expression on admission to hospital in relation to mortality among patients with community-acquired infection

Objective and Design: Prognostic value of markers of systemic inflammation were evaluated in patients admitted to hospital. Material: The study comprises 327 patients with community-acquired infection verified on admission (n = 290) or within 3-day follow-up (n = 37). Methods: On-admission levels of phagocyte CD11b/CD18 and CD14 expression were measured using whole blood flow cytometry. Clinical data were collected retrospectively from medical records. Results: In univariate analysis, non-survivors as compared to survivors had higher age, lower arterial pressure, higher heart rate, and lower monocyte CD 14 density. In multivariate analysis high age [relative mortality RR 1.05 (95% CI 1.01 to 1.08), p = 0.016] and low CD 14 expression on monocytes [RR 7.49 (CI 1.63 to 34.33), p = 0.01] remained predictive for the 28-day mortality. Conclusion: In patients with community-acquired infection, low on-admission level of monocyte CD14 is related to fatal outcome.