Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su

被引：112

作者：

Nogawa, T

Kamano, Y

Yamashita, A

Pettit, GR

机构：

[1] Kanagawa Univ, Fac Sci, Kanagawa 2591293, Japan

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[3] Arizona State Univ, Inst Canc Res, Tempe, AZ 85287 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 09期

关键词：

D O I：

10.1021/np0101088

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new bufadienolides, 3 beta -formyloxyresibubgenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6 alpha -hydroxycinobufagin (4), and 1 beta -hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the EB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line.

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页码：1148 / 1152

页数：5

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