Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons

被引:70
作者
Macchi, Claudio [1 ]
Molino-Lova, Raffaele [1 ]
Polcaro, Paola [1 ]
Guarducci, Lorenzo [1 ]
Lauretani, Fulvio [2 ]
Cecchi, Francesca [1 ]
Bandinelli, Stefania [3 ]
Guralnik, Jack M. [4 ]
Ferrucci, Luigi [5 ]
机构
[1] Fdn Don C Gnocchi, I-50020 Florence, Italy
[2] Tuscany Hlth Reg Agcy, Florence, Italy
[3] ASF, Geriatr Rehabil Unit, Florence, Italy
[4] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
[5] NIA, Clin Res Branch, Longitudinal Studies Sect, Baltimore, MD 21224 USA
关键词
uric acid; antioxidants; sarcopenia; muscle strength; elderly;
D O I
10.1016/j.mad.2008.04.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Background: Previous studies have shown that oxidative protein damage is independently associated with low grip strength and that dietary intake and circulating levels of antioxiclant vitamins are positive predictors of muscle strength among older persons. Since uric acid (LIA), has strong antioxidant properties, we tested the hypothesis that UA levels is cross-sectionaly associated with muscle strength and protective against the decline of strength over the aging process. Subjects and methods: 789 InCHIANTI Study participants underwent baseline serum UA, handgrip and knee extension torque measurements. Of these, 497 participants (226 men and 271 women, mean age 76.0 +/- 5.4 years) also had follow-up strength measures. Lifestyle, comorbidities, nutritional profile, inflammatory markers and other laboratory measures were considered as potential confounders. Results: Follow-up strength measures significantly increased across baseline UA tertiles. After adjusting for potential confounders and analogous baseline strength measures, higher baseline UA levels still remained significantly associated with higher follow-up strength measures. Conclusions: Our findings suggest that higher levels ofUA might represent a protective reaction aimed at counteracting the excessive production offree radicals that cause muscle protein damage and eventually contribute to the decline of muscle mass and strength. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:522 / 527
页数:6
相关论文
共 48 条
[1]
Insulin resistance and muscle strength in older persons [J].
Abbatecola, AM ;
Ferrucci, L ;
Ceda, G ;
Russo, CR ;
Lauretani, F ;
Bandinelli, S ;
Barbieri, M ;
Valenti, G ;
Paolisso, G .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2005, 60 (10) :1278-1282
[2]
Compendium of Physical Activities: an update of activity codes and MET intensities [J].
Ainsworth, BE ;
Haskell, WL ;
Whitt, MC ;
Irwin, ML ;
Swartz, AM ;
Strath, SJ ;
O'Brien, WL ;
Bassett, DR ;
Schmitz, KH ;
Emplaincourt, PO ;
Jacobs, DR ;
Leon, AS .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2000, 32 (09) :S498-S516
[3]
Uric acid and cardiovascular risk [J].
Alderman, MH .
CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (02) :126-130
[4]
Measuring muscular strength of the lower limbs by hand-held dynamometer: A standard protocol [J].
Bandinelli, S ;
Benvenuti, E ;
Del Lungo, I ;
Baccini, M ;
Benvenuti, F ;
Di Iorio, A ;
Ferrucci, L .
AGING-CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 11 (05) :287-293
[5]
Uric acid is a risk factor for myocardial infarction and stroke - The Rotterdam Study [J].
Bos, Michiel J. ;
Koudstaal, Peter J. ;
Hofman, Albert ;
Witteman, Jacqueline C. M. ;
Breteler, Monique M. B. .
STROKE, 2006, 37 (06) :1503-1507
[6]
Cesari M, 2004, AM J CLIN NUTR, V79, P289
[7]
Uric acid administration for neuroprotection in patients with acute brain ischemia [J].
Chamorro, A ;
Planas, AM ;
Muner, DS ;
Deulofeu, R .
MEDICAL HYPOTHESES, 2004, 62 (02) :173-176
[8]
Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis [J].
Coutinho, Thais de A. ;
Turner, Stephen T. ;
Peyser, Patricia A. ;
Bielak, Lawrence F. ;
Sheedy, Patrick F., II ;
Kullo, Iftikhar J. .
AMERICAN JOURNAL OF HYPERTENSION, 2007, 20 (01) :83-89
[9]
Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study [J].
Culleton, BF ;
Larson, MG ;
Kannel, WB ;
Levy, D .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (01) :7-+
[10]
Dominguez LJ, 2006, AM J CLIN NUTR, V84, P419